New research reveals that patients who stop using popular slimming jabs like Wegovy and Mounjaro can put back on shed pounds at a significantly accelerated pace than those who stop traditional diet and exercise regimens.
Published data in a leading health publication shows that while obese individuals frequently drop substantial amounts of their body weight while using the jabs, the mass comes back at an average rate of 0.8 kg per month upon discontinuation.
"Individuals using such treatments should be aware of the danger of rapid rebound weight gain when the therapy concludes," warns lead investigator Dr. Susan Jebb.
That rate of regain suggests a reversion to pre-treatment mass within about a year and a half.
Comparing Treatments
The research, which examined 37 of trials involving over 9,000 of participants, contrasted the effects of the injectable medications with older methods.
Researchers emphasize that people who shed pounds through dieting typically see a slower creep back—approximately 100 grams monthly—after stopping.
Explaining the Quick Rebound
Doctors propose the mode of action of the jabs explains the accelerated weight return.
GLP-1 drugs mimic a body's own chemical called glucagon-like peptide-1, which helps regulate feelings of fullness.
"Sustained high doses of the hormone concentrations far above than normal could lead to the system to produce less of its own natural hormone, and may also lessen sensitivity to its effects," explained Dr. Adam Collins, a nutrition expert.
"Discontinuation of this hormone supplement leads to hunger is unsuppressed, making overeating a significant risk."
An Ongoing Disease?
The NHS advise the injections for individuals with obesity-related medical conditions, accompanied by prescribed diet and exercise modifications.
A number of clinicians contend that, due to the high risk of weight regain, the therapy might need to be long-term.
This opinion is echoed by drug manufacturers, who state that the results "highlight the long-term character of obesity," akin to managing conditions like diabetes.
Patient Testimonies
Individuals who have discontinued the medication explain a intense resurgence of hunger.
"I experienced a trigger that goes on and you're instantly starving," recalled an individual.
This difficulty is worsened if individuals have not established permanent dietary or behavioural changes during therapy.
Widespread Adoption
Recent estimates suggest that millions of people in the UK have used weight-loss jabs in the last 12 months, with demand remaining high.
- Use is higher among females than men.
- The middle-aged age group shows the highest level of interest.
- A large proportion access the drugs through private healthcare rather than public health services.
Ultimately, researchers caution that while these medications are potent agents for weight loss, they are not a permanent fix and lasting health benefits likely depends on integrated lifestyle management.
